Abstract
A rapid and cost-effective approach has been developed to harvest and map the dispensable genome, that is, population-level natural sequence variation within a species that is not present in static genome assemblies.See related Research article: http://www.genomebiology.com/2015/16/1/187.
Highlights
Today’s genome assemblies lack crucial information that is necessary to answer many complex functional and evolutionary questions
The pan-genome can be probed with population re-sequencing data to pinpoint single nucleotide polymorphisms (SNPs) and haplotype and structural variation within the whole species
Wing Genome Biology (2015) 16:217 the indica and japonica assemblies, leading the authors to suggest that the majority of the contig assemblies in each dispensable genome were subpopulation specific
Summary
Today’s genome assemblies lack crucial information that is necessary to answer many complex functional and evolutionary questions. The goal of reference-quality genome-sequencing projects is to provide public access to the majority of a genome, including both gene and repeat space, with high accuracy and contiguity.
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