Abstract
Harvesting of olfactory ensheathing cells for autologous transplantation into the spinal cord injury. Its complexity in dogs.
Highlights
The olfactory sensory neurons (OSNs) are organized into different territories and, with the exception of the OSNs enclosed in the vomeronasal organ, they are directly exposed to the external environment and are vulnerable to physical, chemical or traumatic injuries
In dogs the lamina propria (LP) is especially well developed in the olfactory mucosa (OM) of the posterior part of the nasal septum, near the cribriform plate of the ethmoid bone, and that is the most favorable area to harvest olfactory ensheathing cells (OECs) (Figure 1)
In the dissection room we have observed significant changes in the general conformation of the frontal sinus (FS), in our previous studies (Barrios et al, 2014) we have focused our attention in adult mesaticephalic dogs, that is to say German Shephersds or mongrels derived therefrom
Summary
An alternative would be to go for the transnasal/transseptal/ submucoperiosteal microsurgical approach, which is a part of the traditional transnasal/transsphenoidal approach for treatment of pituitary tumors in humans This technique involves a total or partial destruction of the ventral and middle nasal conchae and the ethmoturbinates in dogs (Figures S1–S3, in Supplementary Material), and the side effects must be rigorously assessed. The FS of dogs, usually integrated by three parts (lateral, rostral, and medial), shows an enormous variability, to the extent that there are not two identical frontal sinuses, and even within the same subject symmetry is not found between the left and right side. All of these facts advise against the consideration of the frontal sinus—its mucosa and/or its contents—as the ideal place to harvest OECs in adult dogs
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
