Abstract
Optical imaging is an emerging technology capable of qualitatively and quantitatively observing life processes at the cellular or molecular level and plays a significant role in cancer detection. In particular, to overcome the disadvantages of traditional optical imaging that only two-dimensionally and qualitatively detect biomedical information, the corresponding three-dimensional (3D) imaging technology is intensively explored to provide 3D quantitative information, such as localization and distribution and tumor cell volume. To retrieve these information, light propagation models that reflect the interaction between light and biological tissues are an important prerequisite and basis for 3D optical imaging. This review concentrates on the recent advances in hybrid light propagation models, with particular emphasis on their powerful use for 3D optical imaging in cancer detection. Finally, we prospect the wider application of the hybrid light propagation model and future potential of 3D optical imaging in cancer detection.
Highlights
Most of the current clinical detection of tumors relies on morphological changes occurring for discrimination, which makes it difficult to see accurately at an early stage
Among the light propagation models based on radiative transfer equation (RTE) and its approximation, Monte Carlo (MC) simulation, diffusion approximation (DA), and spherical harmonics approximation (SPN) are the most frequently chosen in optical tomography (OT)
The HSRM was selected as the forward model of the bioluminescence tomography (BLT) for gastric cancer detection [27], and the results proved that the HSRM-based 3D optical imaging can significantly improve the accuracy of the hybrid radiosity-diffusion model (HRDM)-based one
Summary
Most of the current clinical detection of tumors relies on morphological changes occurring for discrimination, which makes it difficult to see accurately at an early stage. OI is the acquisition of optical signals emitted from the body surface of a living organism, which can reflect the early molecular changes of lesions in the body Such two-dimensional (2D) planar imaging cannot provide accurate depth and location information of the target and is difficult to provide accurate quantitative information. By combining the anatomical structure of the organism and optical parameters of biological tissues, the corresponding three-dimensional (3D) imaging technology, Hybrid Light Propagation Model called optical tomography (OT), can obtain the spatial localization and distribution, as well as the quantitative information of the targeted probes inside the body from the 2D optical images measured on the body surface [5] This is an important method for quantitative detection of early tumor. We prospect the wider application of hybrid light propagation models and future potential of 3D optical imaging in cancer detection
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
