Harnessing MoS2 nanomaterials for TNP sensing and anticancer efficacy

Abstract

This research article addresses the security concerns related to public safety and national security, focusing on the urgent need for rapid and sensitive explosive detection methods, particularly for 2,4,6-trinitrophenol (TNP) due to its impact on healthcare, environment, and homeland security. The study presents a stable and cost-effective solution based on MoS2 nanomaterials for the detection of TNP using both electrochemical and UV–Vis spectrophotometric methods. Notably, TNP can cause skin irritation, eye damage, respiratory issues and ultimately cancer. The proposed smart nanotechnology-based system effectively detects TNP in the environment and exhibits cytotoxicity against CAL-51 and Huh-7 cells with GI 50 value of 285.48 ± 0.06 μg/ml and 78.125 μg/ml, respectively. Both sensing platforms showcased remarkable results in terms of sensitivity, selectivity, replicability, aging, and real sample application. The unique sensing platform demonstrated excellent sensitivity and selectivity within a linear range of 0.001 mM–1 mM, with a low detection limit of 0.013 μM. The real sample application confirmed the potential of MoS2 for TNP detection and its capability to outperform conventional sensing approaches. This research contributes to advancing explosive detection technology for enhanced security and safety measures.