Abstract
Photonic crystal fibres (PCFs) offer precise control over light propagation, making them promising for sensitive bio-sensing applications. This paper proposes a novel PCF sensor for blood cancer detection, leveraging chromatic dispersion as a key sensing mechanism. Our sensor integrates hemoglobin into a 2D PCF structure, enabling the detection of subtle refractive index changes associated with cancer cells. Numerical simulations reveal significant shifts in the zero-dispersion wavelength and slope variations in the dispersion curves when analyzing blood samples with increasing hemoglobin concentrations, exceeding 80%. This distinct behaviour, absent in healthy samples, demonstrates the potential of dispersion-based sensing for cancer diagnosis. The sensor exhibits a sensitivity of 0.0091249, indicating its capability to detect subtle changes in dispersion properties, exceeding the sensitivity of conventional refractive index-based methods. This work highlights the innovative use of chromatic dispersion in PCF sensors, paving the way for early and accurate blood cancer detection and potentially leading to improved treatment outcomes.
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