Abstract
MDMA (3,4-methylenedioxymethamphetamine), often referred to as ‘ecstasy’, has been shown to selectively and persistently impair central serotonergic neurotransmission in laboratory animals. As of recent, evidence in human studies has suggested a link between recreational ecstasy use and a disruption of the brain’s serotonergic system. However, human neurocognitive and neuroimaging studies have yielded inconsistent findings regarding the functional impact of these neuro-adaptations, possibly due to methodological difficulties. Although the literature on the effects of recreational ecstasy use on neurocognitive function remains inconclusive, studies have most consistently shown negative effects on memory. Here, we provide a review of accumulating evidence supporting a link between recreational ecstasy use and impaired memory.
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