Hard-to-heal wounds: A new biofilm treatment with a novel desiccant

Mariana Peroni Mariana Peroni,Renzo Girardello Renzo Girardello,Giampietro Bertasi Giampietro Bertasi,Ornella Pancheri Ornella Pancheri,Stefano Bonvini Stefano Bonvini

doi:10.30574/msabp.2021.3.1.0036

Mariana Peroni Mariana Peroni, Renzo Girardello Renzo Girardello + Show 3 more

Open Access

https://doi.org/10.30574/msabp.2021.3.1.0036

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Abstract

Biofilms are slow-growing communities of multiple strains of bacteria that resist both innate immune mechanisms as well as antibiotics [1] [16] [17]. They also contain extracellular DNA (bacterial or host origin), polysaccharides, and proteins that form dense matrix is resistant to the host’s innate immune response [18] [19].

Highlights

Biofilms are believed to occur in 60-100% of chronic wounds [2] [5]
The World Union of Wound Healing Societies released a position statement that they believe cliniciansshould assume that all chronic wounds that have failed to heal under standard of care contain a biofilm [3] [20]
With resistance to host’s innate immune response With resistance to antibiotics due to slow growth rate o The mechanism for antibiotic function happens during replication, low replication, low antibiotic activity

Summary

Introduction

They contain extracellular DNA (bacterial or host origin), polysaccharides, and proteins that formdense matrix is resistant to the host’s innate immune response [18] [19]. 1. Introduction Biofilms are believed to occur in 60-100% of chronic wounds [2] [5]. The World Union of Wound Healing Societies released a position statement that they believe cliniciansshould assume that all chronic wounds that have failed to heal under standard of care contain a biofilm [3] [20].

Results

Conclusion