Abstract
Haptoglobin (Hp) 2-2 type has been associated with accumulation of atherosclerotic lesions in essential hypertension. The aim of this study was to investigate the relationship between Hp type and the extension of coronary lesions in 765 male patients who underwent coronary artery bypass grafting (CABG). In this group, relative Hp1 (0.418) and Hp2 (0.582) allele frequencies were comparable with those of the reference population. Candidate CABG patients with a Hp 2-2 type were overrepresented in the younger (<45 years) age group ( P<0.05). Hp 2-2 patients needed more bypass grafts than Hp 1-1 patients (relative risk 1.92, 95% C.I. 1.24–2.96). The Hp 2-2 type was overrepresented among victims of a previous acute myocardial infarction ( P<0.05), and among patients with a lower (<45 years) age at infarction ( P<0.05). In patients who already underwent a previous CABG, graft survival time was shortest in Hp 2-2 type ( P<0.05). Patients with a Hp 2-2 type more likely develop atherosclerotic lesions despite comparable serum lipid concentrations.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
