Abstract
These experiments were designed to test whether newt ( Notophthalmus viridescens) immunocytes are able to recognize the hapten, 2,4,6-trinitrophenyl (TNP), separately from a heterologous erythrocyte (RBC) carrier. While a single priming injection with an erythrocyte species which is unrelated to the carrier of the TNP fails to stimulate amplification of the anti-TNP response, sequential (2×) priming provides about 50% as much amplification as a single priming injection of RBC homologous with the carrier. The anti-carrier response is not increased by sequential priming with the unrelated RBC. Moreover, sequential priming with RBC homologous with the carrier species initiates a suppression of the anti-hapten response without affecting anti-carrier activity levels. Thus the recognition and regulation of responses to a hapten and its carrier may be unlinked in this species.
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