Abstract
Adiponectin plays an important role in energy homeostasis and metabolism in mammalian adipose tissue. In this study, the relationship between adiponectin gene (ADIPOQ) haplotypes and variation in growth and carcass traits in New Zealand (NZ) Romney lambs was investigated using General Linear Models (GLMs). Eight haplotypes were found in these lambs and they were composed of the four previously reported promoter fragment sequences (A1–D1) and three previously reported intron 2–exon 3 sequences (A3–C3). The frequencies of the haplotypes ranged from 0.07% to 45.91%. The presence of A1–A3 was associated with a decreased pre-weaning growth rate (p = 0.037), and decreased leg lean-meat yield (p = 0.001), loin lean-meat yield (p = 0.018) and total lean-meat yield (p = 0.004). The presence of A1–C3 was associated with increased carcass fat depth over the 12th rib (V-GR; p = 0.001) and a decreased proportion of loin lean-meat yield (p = 0.045). The presence of B1–A3 was associated with an increased proportion of leg lean-meat yield (p = 0.016) and proportion of shoulder lean-meat yield (p = 0.030). No associations were found with birth weight, tailing weight and weaning weight. These results suggest that ovine ADIPOQ may have value as a genetic marker for NZ Romney sheep breeding.
Highlights
Adiponectin (ADIPOQ) is a member of the adipocytokine family of proteins and is secreted primarily by white adipose tissue
Means within a row that do not share a superscript letter are different at p < 0.05 (p < 0.05 in bold and 0.05 ≤ p < 0.10 in italics). b V-GR represents carcass fat depth over the 12th rib. c Lean-meat yield expressed as a percentage of hot carcass weight. d Total lean-meat yield is the sum of the leg, loin and shoulder lean-meat yield. e The proportion lean-meat yield of leg, loin or shoulder lean-meat is the yield of the specific area divided by the total yield expressed as a percentage. This is the first study to report associations between ovine ADIPOQ haplotypes and selected growth and carcass traits in lambs and the findings suggest that this genetic variation may play a role in traits that are of economic importance to sheep farmers
C1 –C3 being described in Merino sheep [18], but not being found in the New Zealand (NZ) Romney lambs in this study
Summary
Adiponectin (ADIPOQ) is a member of the adipocytokine family of proteins and is secreted primarily by white adipose tissue. It is produced by other tissues including bone marrow, brown adipose tissue and skeletal muscle [1,2,3]. It has been demonstrated that ADIPOQ plays an important role in regulating energy homeostasis, and in glucose metabolism and lipid metabolism in humans [4,5]. ADIPOQ levels in adipose tissue are negatively correlated with obesity through the modulation of lipid synthesis, glucose utilisation and fatty acid oxidation [6,7]. ADIPOQ may be an important regulator of growth and carcass traits in livestock. The human adiponectin gene (ADIPOQ) was first identified in 1995 and is located on chromosome
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