Abstract

Haplotypes of the imprinted insulin gene are associated with size for gestational age and umbilical cord IGF-II levels

Highlights

  • UT-ORNL-KBRIN Bioinformatics Summit 2008 Eric C Rouchka and Julia Krushkal Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.kbrin.louisville.edu/summit/

  • When analyzed according to parental origin of haplotypes, paternally transmitted haplotypes were significantly associated with risk of small for gestational age (SGA) and umbilical cord IGFII levels, but maternally transmitted haplotypes were not significantly associated

  • Associations of individual SNPs and inferred haplotypes with risk of small for gestational age (SGA) birth were tested using logistic regression, and mean umbilical cord IGF-II levels were compared by ANOVA

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Summary

Objective

To test the association between haplotypes in the insulin – insulin-like growth factor 2 (IGF2) locus and both risk of small for gestational age birth and umbilical cord IGFII levels. 207 pairs of healthy African-American full-term, newborn and mothers from Memphis, Tennessee and Jackson, Mississippi

Methods
Results
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