Haplotype dependent association of rs7927894 (11q13.5) with atopic dermatitis and chronic allergic rhinitis: A study in ECAP cohort.

Joanna Kinga Ponińska,Grażyna Kostrzewa,Agnieszka Lipiec,Edyta Krzych-Fałta,Piotr Samel-Kowalik,Aneta Tomaszewska,Barbara Piekarska,Rafał Płoski,Andrzej Namysłowski,Artur Walkiewicz,Piotr Kuśnierczyk,Sławomir Majewski,Andrzej Wiśniewski,Andrzej Pawlik,Monika Jasek,Filip Raciborski,Bolesław Samoliński,Anna Carla Goldberg

doi:10.1371/journal.pone.0183922

Abstract

The T allele of rs7927894 (at 11q13.5) was associated with atopic dermatitis and other allergic diseases. Our purpose was to replicate the association with allergic phenotypes and explore the role of rs7927894 in predisposing to persistent allergic rhinitis and atopic asthma. We also wanted to explore if other SNPs at 11q13.5 contributed to effect of rs7927894. We studied patients with atopic dermatitis (N = 270), atopic asthma (N = 486), persistent allergic rhinitis (N = 589) and controls matched for age, sex and region (N = 540, N = 372 and N = 1178, respectively). We found that rs7927894 T was associated with atopic dermatitis (OR = 1.39, CI: 1.12–1.73, P = 0.003) and independently with persistent allergic rhinitis (OR = 1.24, CI:1.07–1.43, P = 0.0043, Pcorrected = 0.013) but not atopic asthma. Analysis of additional tagging SNPs (rs7930763, rs2513517, rs7125552) showed that effect of rs7927894 T was limited to haplotypes encoding G at rs7125552. In conclusion, rs7927894 T is associated not only with atopic dermatitis but also persistent allergic rhinitis. Since these effects are haplotype dependent rs7927894 alone does not account for the association between 11q13.5 and atopic dermatitis/persistent allergic rhinitis.

Highlights

Allergy is the most common disease in developmental age
The T allele of rs7927894 is associated with atopic dermatitis (AD) and persistent allergic rhinitis
We found that the T allele of rs7927894 was overrepresented among AD and persistent allergic rhinitis (pAR) patients compared to the matched controls (Table 1)

Summary

Introduction

Allergy is the most common disease in developmental age. The prevalence rate is almost 40% of the population in developed countries with trends for increase [1]. The strongest hypothesis explaining this high prevalence is related to the hygienic character style of life in neonatal age [2]. 11q13.5 variants vs allergy collection and analysis, decision to publish, or preparation of the manuscript

Methods

Results

Conclusion