Abstract
Common variable immunodeficiency (CVID) is a disease in which patients show a weak immune response and susceptibility to recurrent infections. With age, CVID patients can develop additional complications, including autoimmune disease and cancer, which can significantly shorten their lives. CVID develops due to mutations in genes that are ordinarily critical for the immune system. The most commonly affected gene in Europeans is NFKB1. However, it was unclear why the NFKB1 gene is required to prevent CVID. This project studied the function of NFκB1 in mice and identified several mechanisms that could give rise to CVID in the relevant human patients.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
