Abstract
We identified cytochrome P450 (P450) isozymes that are involved in the formation of two active sibutramine (<i>N</i>-{1-[1-(4-chlorophenyl)-cyclobutyl]-3-methylbutyl}-<i>N</i>,<i>N</i>-dimethylamine) metabolites, M1 (<i>N</i>-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-<i>N</i>-methylamine) and M2 (1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine), in humans using a combination chemical inhibition,...
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