Abstract

We describe the first handheld, swept source optical coherence tomography (SSOCT) system capable of imaging both the anterior and posterior segments of the eye in rapid succession. A single 2D microelectromechanical systems (MEMS) scanner was utilized for both imaging modes, and the optical paths for each imaging mode were optimized for their respective application using a combination of commercial and custom optics. The system has a working distance of 26.1 mm and a measured axial resolution of 8 μm (in air). In posterior segment mode, the design has a lateral resolution of 9 μm, 7.4 mm imaging depth range (in air), 4.9 mm 6dB fall-off range (in air), and peak sensitivity of 103 dB over a 22° field of view (FOV). In anterior segment mode, the design has a lateral resolution of 24 μm, imaging depth range of 7.4 mm (in air), 6dB fall-off range of 4.5 mm (in air), depth-of-focus of 3.6 mm, and a peak sensitivity of 99 dB over a 17.5 mm FOV. In addition, the probe includes a wide-field iris imaging system to simplify alignment. A fold mirror assembly actuated by a bi-stable rotary solenoid was used to switch between anterior and posterior segment imaging modes, and a miniature motorized translation stage was used to adjust the objective lens position to correct for patient refraction between -12.6 and + 9.9 D. The entire probe weighs less than 630 g with a form factor of 20.3 x 9.5 x 8.8 cm. Healthy volunteers were imaged to illustrate imaging performance.

Highlights

  • As optical coherence tomography (OCT) develops into an important tool for anterior segment characterization, the ability to use a single instrument for both anterior and posterior segment imaging may become a desirable feature for clinical systems

  • All of the hardware was controlled using custom graphics processing unit (GPU)-accelerated software written in C++ to provide real-time display of OCT images

  • We have demonstrated a microelectromechanical systems (MEMS)-based handheld dual depth swept source optical coherence tomography (SSOCT) system that enables rapid, sequential imaging of the anterior segment and retina

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Summary

Introduction

As optical coherence tomography (OCT) develops into an important tool for anterior segment characterization, the ability to use a single instrument for both anterior and posterior segment imaging may become a desirable feature for clinical systems. Several commercial ophthalmic OCT systems are capable of switching between anterior and posterior imaging modes; this requires the addition or removal of optics from the sample path and adjustment of the reference path. A few of these instruments are capable of imaging both the anterior and posterior segment [2,3,4, 7], but switching between modes requires the operator to remove and/or add an additional lens or lens system. This distracts the operator from the patient and requires realignment with the patient eye after switching modes

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