Year-end Sale % OFF 
Abstract
The newly developed radioisotope-free technique based on magnetic nanoparticle detection using a magnetic probe is a promising method for sentinel lymph node biopsy. In this study, a novel handheld magnetic probe with a permanent magnet and magnetic sensor is developed to detect the sentinel lymph nodes in breast cancer patients. An outstanding feature of the probe is the precise positioning of the sensor at the magnetic null point of the magnet, leading to highly sensitive measurements unaffected by the strong ambient magnetic fields of the magnet. Numerical and experimental results show that the longitudinal detection length is approximately 10 mm, for 140 μg of iron. Clinical tests were performed, for the first time, using magnetic and blue dye tracers—without radioisotopes—in breast cancer patients to demonstrate the performance of the probe. The nodes were identified through transcutaneous and ex-vivo measurements, and the iron accumulation in the nodes was quantitatively revealed. These results show that the handheld magnetic probe is useful in sentinel lymph node biopsy and that magnetic techniques are widely being accepted as future standard methods in medical institutions lacking nuclear medicine facilities.
Highlights
Sentinel lymph node biopsy (SLNB) is performed to investigate tumor metastases and determine the appropriate sequence of care for breast cancer patients[1,2,3]
A clinical study using the magnetometer and SPION tracers was performed on breast cancer patients[19], and subsequent studies revealed that the magnetic technique was not inferior to the radioisotope technique[20,21,22,23,24,25], which indicated that the technique could be a prospective standard method without any limitations
The SPIO tracers accumulated in the sentinel lymph node (SLN) are magnetized by the magnetic fields of the permanent magnet enclosed in the head of the magnetic probe (Fig. 1(b)), and subsequently, the SLNs containing the magnetic nanoparticles are identified by measuring the magnetic fields newly generated from the magnetized nanoparticles[19,20,29,30,31,32]
Summary
Sentinel lymph node biopsy (SLNB) is performed to investigate tumor metastases and determine the appropriate sequence of care for breast cancer patients[1,2,3]. A handheld magnetometer that can be used at room temperatures, i.e., without a refrigerant, has been developed as a magnetic technique to detect the SLNs in breast cancer patients. A clinical study using the magnetometer and SPION tracers was performed on breast cancer patients[19], and subsequent studies revealed that the magnetic technique was not inferior to the radioisotope technique[20,21,22,23,24,25], which indicated that the technique could be a prospective standard method without any limitations. We performed the first ever clinical test with SPIONs and blue dye (without radioisotopes) tracers to demonstrate the performance of the prototype magnetic probe in SLNB for breast cancer patients. The SPIO tracers accumulated in the SLNs are magnetized by the magnetic fields of the permanent magnet enclosed in the head of the magnetic probe (Fig. 1(b)), and subsequently, the SLNs containing the magnetic nanoparticles are identified by measuring the magnetic fields newly generated from the magnetized nanoparticles[19,20,29,30,31,32]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
