Abstract
Background: Ablative fractional CO2 laser (AFCL) has been reported to be safe and effective to use for preventing hand photoaging in a recent pilot study. Objectives: This study aimed to evaluate the efficacy of AFCL in improvement of hand photoaging in 25 patients. Patients and Methods: A prospective, before- after, single blind study was conducted in 25 patients who presented for desired treatment of hand photoaging. Patients received three treatments sessions with AFCL. Results: All enrolled patients were female and received three treatment sessions. There was no incidence of significant adverse effects such as scarring, prolonged erythema sever edema, post inflammatory pigmentary changes, or infection. Mean improvement one month after three treatments was 48.3% (95% CI, 42.6 - 53.9) for skin wrinkling, 53.3% (95% CI, 47.9 - 58.8) for skin pigmentation, 46.9% (95% CI, 41.4 - 52.2) for skin texture, and 54.9% (95% CI, 49.3 - 60.5) for overall cosmetic outcome (all P < 0.05). Conclusions: AFCL can be used safely and effectively in the treatment of hand photoaging.
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