Abstract
Plant-derived products can assist in the healing process of dermal wounds. It has been demonstrated that Hancornia speciosa latex present angiogenic, osteogenic, anti-inflammatory, and antioxidant activities. Then, it could contribute to the wound healing process. However, natural products in contact with skin may cause dermatitis. The objective of this work was to evaluate the allergic and irritant potential of H. speciosa serum fraction latex using in vitro assays. The obtained results showed that the H. speciosa serum fraction latex has a slightly irritant potential and is not cytotoxic neither allergenic for human cells. Moreover, we identified a remarkable low amount of proteins in this material in comparison to Hevea brasiliensis latex. This result could explain the non-allergenic potential of H. speciosa serum fraction latex because proteins present in latex are the main responsible for allergy. This biomaterial could be used as a non-allergenic source for development of new medicines.
Highlights
The healing of chronic wounds is considered a public health problem because of the protracted and intensive high-cost treatment, which could require prolonged hospitalizations, home care, complex treatments, and adjuvant therapies (Cavassan et al, 2019)
Researchers are looking for products or strategies to accelerate the wound healing process and topical treatments using natural products can be useful in this process
We investigated the irritant and allergenic potential of the H. speciosa serum latex to verify if this biomaterial could be further safely used in a new non-allergenic formulation with potential healing for skin wound treatment
Summary
The healing of chronic wounds is considered a public health problem because of the protracted and intensive high-cost treatment, which could require prolonged hospitalizations, home care, complex treatments, and adjuvant therapies (Cavassan et al, 2019). Researchers are looking for products or strategies to accelerate the wound healing process and topical treatments using natural products can be useful in this process. Topical wound-care therapies using natural products has the advantage of low cost when compared to conventional wound-care products. An example of a natural product with wound healing properties is the natural rubber latex (NRL). The NRL is the main compound of the commercial products called Biocure® and Regederm®, which are medicines able to stimulate angiogenesis and granulation tissue growth, accelerating the wound healing process (Biocure Pharma Biotechnology, 2021). The obtained results with those products showed the excellent potential of NRL to produce tissues replacement and regeneration
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