Hamster to rat kidney transplantation: technique, functional outcome and complications.

Abstract

Hamster to rat kidney transplantation has only recently been introduced as model of concordant xenografting. The kidney model offers unique possibilities for studying both immunological and functional aspects of xenografts as opposed to the widely used heterotopic heart model. This article provides a detailed description of surgical technique as well as data on functional outcome and complications. The renal artery with a small segment of the aorta is sutured end-to-side to the abdominal aorta of the recipient, and the renal vein is anastomosed end-to-side to the inferior vena cava. The urinary system is reconstructed by bladder-to-bladder anastomosis. Xenografts will maintain close to normal serum-creatinine levels for 2-3 days, after which they are rejected. Complications occurred in 22% of xenografts. Postrenal obstruction due to severe hematuria or ureter stenosis was the most frequent problem encountered.