Abstract

AbstractA one‐pot synthesis of 1‐methyl‐ and 1‐phenylpyrazole‐3(5)‐ethyl esters 2,3a‐e by the cyclocondensation of β‐alkoxyvinyl trichloromethyl ketones 1a‐e with methyl and phenyl hydrazine hydrochloride under mild conditions, is reported. A study using compounds 1a‐e with different substituents proved that these are versatile building blocks for the synthesis of pyrazole derivatives, having a 3(5)‐ethoxycarbonyl substituent in good yields (60–89%). The hydrazine and β‐alkoxyvinyl trichloromethyl ketone substituent effects on the reaction regiochemistry on the formation of the 1,3‐ and 1,5‐isomer were observed.

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