Abstract
A new dimeric sesquiterpenoid with two eudesmane skeletons through a urea linkage, halichonadin A ( 1 ), as well as three new eudesmane sesquiterpenoids having a carbamate, an isonitrile, or an amino functionality, halichonadins B ( 2 ), C ( 3 ), and D ( 4 ), respectively, have been isolated from a marine sponge Halichondria sp., and the gross structures and relative stereochemistry of 1– 4 were elucidated on the basis of spectral data and chemical means.
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