Abstract
Separation of an extract of a Xestospongia sp., guided by bioassay against Cdc25B, led to the isolation of nine compounds, halenaquinone ( 1), xestoquinone ( 2), adociaquinones A ( 3) and B ( 4), 3-ketoadociaquinones A ( 5) and B ( 6), tetrahydrohalenaquinones A ( 7) and B ( 8), and 13- O-methyl xestoquinol sulfate ( 9). The structures of the new natural products 6 and 9 were established on the basis of extensive one- and two-dimensional NMR studies. Compounds 1, 4, and 6 inhibited recombinant human Cdc25B in vitro with IC 50 values of 0.7, 0.07, and 0.2 μM, respectively, and were 19- to 150-fold less active against two related protein phosphatases. Compound 4 blocked cell cycle progression through mitosis.
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