Abstract
Metabolomics is a powerful tool used to understand comprehensive changes in the metabolic response and to study the phenotype of an organism by instrumental analysis. It most commonly involves mass spectrometry followed by data mining and metabolite assignment. For the last few decades, hair has been used as a valuable analytical sample to investigate retrospective xenobiotic exposure as it provides a wider window of detection than other biological samples such as saliva, plasma, and urine. Hair contains functional metabolomes such as amino acids and lipids. Moreover, segmental analysis of hair based on its growth rate can provide information on metabolic changes over time. Therefore, it has great potential as a metabolomics sample to monitor chronic diseases, including drug addiction or abnormal conditions. In the current review, the latest applications of hair metabolomics in animal studies and clinical settings are highlighted. For this purpose, we review and discuss the characteristics of hair as a metabolomics sample, the analytical techniques employed in hair metabolomics and the consequence of hair metabolome alterations in recent studies. Through this, the value of hair as an alternative biological sample in metabolomics is highlighted.
Highlights
Metabolome is a term that refers to a collection of metabolites present in cells, tissues, organs, and organisms
We review and discuss the characteristics of hair as a metabolomics sample, the analytical techniques used, and the consequences of hair metabolome alterations from previous studies
Since our current study focuses on hair metabolomics, a PubMed search of ‘hair’ and ‘metabolomics or metabolome’ was run, and it yielded 50 articles published between 2008 and 2019
Summary
Metabolome is a term that refers to a collection of metabolites present in cells, tissues, organs, and organisms. The latest applications of hair metabolomics in animal studies and clinical settings are highlighted For this purpose, we review and discuss the characteristics of hair as a metabolomics sample, the analytical techniques used, and the consequences of hair metabolome. Relevant articles from hair has many advantages as a bioanalytical sample, including effortless sample collection, convenient the reference lists were considered in the discussion of hair analysis and metabolomics transport and storage, and repeated sampling [18,19,20,22]. For this purpose, we review and discuss the characteristics of hair as a metabolomics sample, the analytical techniques used, and the consequences of hair metabolome alterations from previous studies. The value of hair as an alternative sample in metabolomics is highlighted
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