Abstract
Depigmentation of hair shafts is a hallmark of human aging. However, it remains unclear how aging causes human hair to grey. Here, we found that a single session of hair plucking via waxing causes hair to grey in castrated mice. Moreover, this hair greying continued for several hair cycles. Given that androgen secretion decreases with age in both male and female humans, the present result suggests that this decrease may contribute to age-related hair greying. In addition, our experimental procedure may represent an effective way to generate a new mouse model of hair greying without the need for genetic engineering.
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