Abstract
The plurality of function and complex differentiation of hair follicle epidermis means that this tissue may have more than one stem cell location. Progenitor cells isolated from the extreme base of the hair follicle, have been shown to have original and highly specialized properties by their morphology and behaviour in vitro, and their capacity to influence dermal differentiation. We have questioned whether production of six or seven distinct epidermal cell types comes from a single progenitor stock. As an alternative we suggest a division of the productive load, where the sources of the inner root sheath and fibre differ, and their composite populations may represent different stages in the same cell lineage, rather than totally separate differentiation states.
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