Abstract
Hair coloring products are one of the most important cosmetics for modern people; there are three major types of hair dyes, including the temporary, semi-permanent and permanent hair dyes. The selected hair dyes (such as ammonium persulfate, sodium persulfate, resorcinol and lawsone) are the important components for hair coloring products. Therefore, we analyzed the effects of these compounds on melanogenesis in B16-F10 melanoma cells. The results proved that hair dyes resorcinol and lawsone can reduce the production of melanin. The results also confirmed that resorcinol and lawsone inhibit mushroom and cellular tyrosinase activities in vitro. Resorcinol and lawsone can also downregulate the protein levels of tyrosinase and microphthalmia-associated transcription factor (MITF) in B16-F10 cells. Thus, we suggest that frequent use of hair dyes may have the risk of reducing natural melanin production in hair follicles. Moreover, resorcinol and lawsone may also be used as hypopigmenting agents to food, agricultural and cosmetic industry in the future.
Highlights
Hair is an essential feature that plays a key role in self-perception
We investigated the effects of commonly used hair dyes on melanogenesis in B16-F10 melanoma cells
We analyzed the effects of chosen hair dyes, ammonium persulfate, sodium persulfate, resorcinol and lawsone, on the melanogenesis in B16-F10 cells
Summary
Hair is an essential feature that plays a key role in self-perception. Sometimes, it expresses people’s personality. Semi-permanent hair dyes are generally synthetic and are typically composed of relatively low molecular weight coal tar materials. These dyes can diffuse freely in and out of the cortex and remain on the hair longer than a temporary dye [1,5]. Melanogenesis (melanin synthesis) is an oxidative chemical reaction, which depends on an important rate-limiting enzyme (tyrosinase) within melanocytes in the parts of skin and hair follicles. We analyzed the effects of selected hair dyes (namely, ammonium persulfate, sodium persulfate, resorcinol and lawsone) on the melanogenesis in B16-F10 melanoma cells in order to confirm the potential of hair dyes on hypo-pigmentation effects. B16-F10 cells, in order to verify the possible mechanisms of selected hair dye effects on the production of melanin in cells
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