Abstract
BackgroundThis study investigated the effects that hair dye use and regular exercise exert on the risk and prognosis of prostate cancer.MethodsWe studied 296 cases of histologically confirmed prostate cancer and 296 age- (in 2-y bands), ethnicity-, and hospital-matched controls in Taiwan between August 2000 and December 2008. To determine the rate of prostate cancer survival, another 608 incident prostate cancer cases occurring between August 2000 and December 2007 were investigated. Information on hair dye use and regular exercise was obtained using a standardized questionnaire.ResultsThe use of hair dyes was associated with a significant 2.15-fold odds of developing prostate cancer (adjusted odds ratio = 2.15, 95 % confidence interval [CI] = 1.32–3.57), but was not associated with prostate cancer survival, compared with no use. The significant risks were more prominent in users aged < 60 years who had used hair dyes for > 10 years, > 6 times per year, and started using hair dyes before 1980. By contrast, regular exercise significantly reduced the number of prostate-cancer-specific death (adjusted hazard ratio = 0.37, 95 % CI = 0.16–0.83); the protective effect of exercise was more prominent among cancer patients who exercised daily (≥7 times/week). However, exercise could not prevent the development of prostate cancer.ConclusionsHair dye use increased the risk of prostate cancer, whereas regular exercise reduced the number of prostate-cancer-specific deaths.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-016-2280-7) contains supplementary material, which is available to authorized users.
Highlights
This study investigated the effects that hair dye use and regular exercise exert on the risk and prognosis of prostate cancer
Study populations To investigate the risk of prostate cancer, we conducted a hospital-based case–control study at 2 large medical centers: Kaohsiung Medical University Hospital (KMUH) and Kaohsiung Veterans General Hospital (KVGH), located in Southern Taiwan
To investigate the survival rate of patients with prostate cancer, we conducted a case-only study, recruiting patients newly diagnosed with adenocarcinoma of the prostate at the Third Medical Center at National Taiwan University Hospital (NTUH) in Northern Taiwan between August 2000 and December 2007
Summary
This study investigated the effects that hair dye use and regular exercise exert on the risk and prognosis of prostate cancer. Accumulated evidence has indicated that 80 to 90 % of human cancers might be attributable to environmental and lifestyle factors such as dietary or cosmetic habits, physical activities, and substance use [5,6,7]. Among these factors, hair dye use and regular exercise are 2 common practices in daily life [8, 9].
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