Abstract
BALB/c mice bearing the transplanted lymphoid tumour ABE-8 developed increased levels of neutrophil, macrophage and eosinophil progenitor cells in the marrow and spleen. Neutrophil-macrophage progenitors, assayed as granulocyte-macrophage colony-forming cells in agar, increased in number only if invasion of the marrow or spleen by ABE-8 cells was demonstrable. Rises in B-lymphocyte colony-forming cells occurred whether or not there was invasion of the host spleen or marrow. No increase in progenitor cells was found in mice bearing diffusion chambers containing ABE-8 cells. The magnitude of leukaemic infiltration was determined by assaying numbers of leukaemic stem cells in the spleen and marrow using a selective cloning system. This transplanted lymphoid leukaemia appears to be a useful model for analysing the effects of haemopoietic tumours on host haemopoietic tissues.
Highlights
Summary.-BALB/c mice bearing the transplanted lymphoid tumour ABE-8 developed increased levels of neutrophil, macrophage and eosinophil progenitor cells in the marrow and spleen
This transplanted lymphoid leukaemia appears to be a useful model for analysing the effects of haemopoietic tumours on host haemopoietic tissues
The BALB/c B-lymphocyte tumour ABE-8, colonies were removed with a fine Pasteur originally induced by the Abelson virus, was pipette and placed on albumin-coated microobtained from Dr M
Summary
Summary.-BALB/c mice bearing the transplanted lymphoid tumour ABE-8 developed increased levels of neutrophil, macrophage and eosinophil progenitor cells in the marrow and spleen. The magnitude of leukaemic infiltration was determined by assaying numbers of leukaemic stem cells in the spleen and marrow using a selective cloning system This transplanted lymphoid leukaemia appears to be a useful model for analysing the effects of haemopoietic tumours on host haemopoietic tissues. Experiments showed that the Erhlich ascites tumour produced granulocyte-macrophage colony stimulating factor in vivo and in vitro. It has been shown (Smith et al, 1960) that mice inoculated with plasma-cell tumours had lowered antibody titres, partly attributed to a reduction in the number of antibody-producing cells after immunization. Claesson & Johnson (1978) found that animals bearing either s.c. transplanted B or T lymphomas or a mammary carcinoma responded with increased levels of B-lymphocyte precursor cells, but only during the period of exponential tumour growth
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