Abstract
Observations are reported on the survival of 51Cr-labelled glucose-6-phosphate dehydrogenase (G-6-PD) deficient cells transfused into normal recipients before and after the administration to the recipient of trimethoprim and sulphamethoxazole, alone or in combination, in varying doses. Trimethoprim did not reduce the T 1 2 of the transfused deficient red cells. In 4 of 6 instances sulphamethoxazole did so but only in the somewhat high dose of 90 mg./kg./day, the T case1 2 being unaffected by smaller doses. However it cannot be concluded from the foregoing that the haemolysis of G-6-PD deficient red cells, provoked by sulphamethoxazole is dose dependent, for severe intravascular haemolysis has been encountered in 2 G-6-PD deficient patients with trivial infections within 48 hours of starting to take 30 mg./kg./day of sulphamethoxazole. It is concluded that the drug should be administered to those of ethnic groups in which this deficiency is common only when the deficiency has been excluded.
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