Abstract
The Journal is the primary organ of Continuing Paediatric Medical Education in Sri Lanka. The journal also has a website. Free full text access is available for all readers.The Sri Lanka Journal of Child Health is now indexed in SciVerse Scopus (Source Record ID 19900193609), Index Medicus for South-East Asia Region (IMSEAR), CABI (Centre for Agriculture and Bioscience International Global Health Database), DOAJ and is available in Google, as well as Google Scholar.The policies of the journal are modelled on the Committee on Publication Ethics (COPE) Guidelines on Principles of Transparency and Best Practice in Scholarly Publishing. Sri Lanka Journal of Child Health is recognised by the International Committee of Medical Journal Editors (ICMJE) as a publication following the ICMJE Recommendations.
Highlights
Maternal red cell antibodies are the commonest cause of Haemolytic Disease of Newborn (HDN)
Maternal red cell antibodies to Rh and ABO blood group systems are commonly responsible for the blood group incompatibilities in HDN., There are several other clinically significant red cell antibodies including MNS blood group system which can cause HDN
Antigens of the MNS blood group system are expressed in the red cell (RBC) membrane on two sialic acid-rich glycoproteins, glycophorin A (GPA) and glycophorin B (GPB)
Summary
Maternal red cell antibodies are the commonest cause of Haemolytic Disease of Newborn (HDN). Rh and ABO antibodies are responsible for most cases, other minor red cell antibodies remain a significant but uncommon cause of HDN1. We report a Sri Lankan baby girl who developed HDN with severe neonatal jaundice due to anti-Mur, one of the minor group red cell antibodies. Antenatal blood sugar screening in the mother did not reveal diabetes mellitus. Blood pictures of both parents were normal. Blood groups of mother and the baby were O positive and O negative respectively. Mother’s direct and indirect antiglobulin tests were negative. Antibody screening of the mother revealed antibodies to Mur antigen, following which a diagnosis of HDN due to antiMur was made. Parental counselling was done regarding the risk of HDN in future pregnancies
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