Abstract
Purpose: Retinopathy of prematurity (ROP), an abnormal proliferation of retinal vessels in premature infants with low birth weight, develops due to many factors. This study investigated a possible correlation between haematological parameters and ROP development. Method: This study included 189 infants without ROP and 128 with ROP. All were born at 35 weeks’ gestation or earlier, had a CBC drawn within 72 hours of birth, and had haemogram data for the first month. Haemoglobin (Hb), haematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), red cell distribution width (RDW), platelet counts (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) values were obtained from hospital data and retrospectively analysed. Results: The mean gestational age was 31 weeks and 29 weeks for the control and ROP groups, respectively; the mean birth weights were 1757 g and 1332 g, respectively. The ROP group’s birth Hb, MCV and RDW were significantly lower than the control group (p p p p
Highlights
Retinopathy of prematurity (ROP) is a disease caused by abnormal proliferation of retinal vessels in infants with low birth weight and preterm birth [1] [2]
Haemoglobin (Hb), haematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), red cell distribution width (RDW), platelet counts (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) values were obtained from hospital data and retrospectively analysed
The values of red blood cell count (RBC), Hb, MCV, MCH, RDW were significantly lower (p < 0.001) and the values of MCHC, PLT, MPV were significantly higher in the infants who developed ROP than in the infants who did not develop ROP
Summary
Retinopathy of prematurity (ROP) is a disease caused by abnormal proliferation of retinal vessels in infants with low birth weight and preterm birth [1] [2]. Phase 1 infants, who are normally in a hypoxic environment in the mother’s womb, are exposed to high concentrations of oxygen in the atmosphere due to premature birth. This is the phase that causes the inhibition of retinal vascularisation in the immature retina resulting from a reduction in the release of vascular endothelial growth factor (VEGF), while receiving O2 therapy due to the immature lungs. In Phase 2, a proliferation of usually abnormal, and rarely normal, vessels appear due to the release of hypoxia-related VEGF resulting from inhibition of retinal vascularisation
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