Abstract
The present study was undertaken to investigate changes in haematology parameters over the course of gestation in Sprague–Dawley rats. Blood samples were alternatively collected from two groups of pregnant rats on gestational days (GD) 0, 3, 6, 9, 12, 15, 18 and 21 using a needle catheter. Red blood cell counts, haemoglobin and haematocrit on GD 6, 12, 18 and 21 were lower than those of normal non-pregnant rats. These values declined progressively during the course of gestation and reached minimum levels on GD 18 or 21. There were no differences in mean corpuscular volume, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration between pregnant and non-pregnant rats. Platelet counts in pregnant rats increased gradually with advancing gestation and were much higher on GD 15 and 21 than in nonpregnant rats. Total white blood cell and lymphocyte counts on GD 0–15 were higher than those of non-pregnant rats. These values increased maximally by GD 6 and then decreased progressively to a nadir on GD 21. Neutrophil counts on GD 9–21 were higher than non-pregnant rat values. The neutrophils increased to a peak level on GD 12 and then steadily decreased. These data can be used not only as a historical database for the effective evaluation of data from reproductive toxicology studies, but also as a contribution to biological characterisation of Sprague–Dawley rats.
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