Abstract
Chronic renal failure is one of the more common causes of morbidity and mortality among Sudanese. This study describes altered haemoglobin concentration (Hb), haematochrit percent (Hct), red blood cells count (RBCs), platelet count (Plts) and white blood cells count (WBCs) in patients with chronic renal failure and describes the effect of disease duration on haemoglobin concentration and red blood cells count. Methods: Haematological parameters in (50) patients with Chronic renal failure and (50) age and sex matched controls were evaluated, living in Shendi locality in northern Sudan. The results of this study showed that mean of Hb concentration, RBCs count, Hct percent and platelet count were exhibited significant decreased, but mean of WBCs count was insignificantly increased. Increased duration of the disease lead to significantly decreased on mean of Hb concentration and RBCs count. Chronic renal failure is associated with different degrees of reduced haematological parameters. Also increase duration of the disease lead to significantly decrease in mean of Hb concentration and RBCs count.
Highlights
Renal failure is a medical condition in which the kidney fails to adequately filter waste product from blood [1].Normal renal function is very important for homeostasis, so much so, that situations in which renal functions are impaired can be life threatening
Anemia parallels the degree of renal impairment and its most important cause is failure of renal erythropoietin secretion
This is a cross-sectional descriptive study based on laboratory data of (50) patients with chronic renal failure hospitalized in Elmak neimer hospital university in Shendi locality and compared with (50) age and sex matched controls
Summary
Renal failure is a medical condition in which the kidney fails to adequately filter waste product from blood [1]. Normal renal function is very important for homeostasis, so much so, that situations in which renal functions are impaired can be life threatening. In United States (35,000) deaths are attributed yearly to renal diseases. The rate of kidney disease mortality in the United States has increased by (52%) in the past 16 years and continues to be higher in blacks than whites[4]. Millions of persons are affected annually by non-fatal kidney diseases, most notably infections of the kidney or lower urinary tract, kidney stones and urinary obstruction. Twenty percent of all women suffer from infection of the urinary tract of kidney at some time in their lives and at least (1%) of the U.S population develops renal stones [5]. Anemia parallels the degree of renal impairment and its most important cause is failure of renal erythropoietin secretion. Other factors include chronic blood loss, hemolysis and bone marrow suppression by retained uremic factors [6]
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