Abstract
Heamatological and pathohistological evidences of Oreochromis niloticus mean 7.00g ± 0.04 fed oxalic acid supplemented diets was investigated under bio-essays laboratory culture for 90 days fed trial, the haematology indices of O. niloticus indicate that there were significant variations (p<0.05) in the haemoglobin (Hb) Pack Cell Volume PCV, with highest WBC was recorded in OAC1 and lowest RBC, the highest MCHC was significant different fron the CTR likewise MCV. This pathohistological examination indicate that the liver, kidney and intestine of fish challenged with entero-toxigenic bacteria (Escherichia coli) exhibited diffused, necrotized, hepatic variation tissues with fatty changes in the hepatic parachyma and vacuolation of hepatic parenchyma cell wall. The finding indicates that the varying inclusion level of oxalic acid in supplemented fed O. niloticus had positive effects on the health status as it increase immmonic system of the fish to fight redant the growth of Escherichia coli bacteria.
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