Haematobiochemical Study on Effect of Linum usitatissimum (Fax Seed) and Emblica officinalis (Amla) Against Lead Toxicity in Wistar Rats

Abstract

The rationale of current study was to observe the effects of lead acetate on haematobiochemical parameter and impact of Linum usitatissimum (Flax seed) and Emblica officinalis (Amla) in Wistar rats. 108 adult Wistar albino rats were randomly assigned into six groups consisting of 18 rats in each, where Group I served as control and they received distilled water. Group II provided with lead acetate @ 60 mg/ kg b.wt., Group III had Emblica officinalis @ 100 mg/ rat/ day, Group IV was fed with Linum usitatissimum @ 300 mg/ kg b.wt, Group V was given lead acetate @ 60 mg/ kg b.wt + Emblica officinalis @ 100 mg/ rat/ day and Group VI received lead acetate @ 60 mg/ kg b.wt + Linum usitatissimum @ 300 mg/ kg b.wt. for 45 days. The mean TEC, Hb, PCV, lymphocyte were reduced significantly (P<0.05) and TLC, Neutrophil count were increased significantly (P<0.05), whereas, significant reduction (P<0.05) in mean protein level and significant (P<0.05) elevation in mean ALT, AST, cholesterol, creatinine, ALP and LDH levels were estimated in serum of lead treated rats as duration dependent manner. The levels of all above parameters were significantly improved in the ameliorated group (Group V and VI). The observations made in the study indicated that co-administration of Amla and Flax seed to rats concurrently with lead was shown to have ameliorating effect on haematobiochemical alteration induced by Lead (Pb) and the ameliorating effect of Emblica was found to be relatively better than that of Flax seed.