Haematobiochemical alterations by lead acetate toxicity and its amelioration with Andrographis paniculata mediated selenium nanoparticles in mice

Abstract

Toxicity of lead acetate and its amelioration with Andrographis paniculata mediated selenium nanoparticles on hematobiochemical parameters in mice was studied. Total 32 male Swiss Albino mice were divided into 4 equal groups. Group T1 was served as control, while T2 group was treated with lead acetate @ 20 mg/kg b. wt. T3 group was treated with Andrographis paniculata mediated selenium nanoparticles @ 5mg/kg b.wt and T4 group was treated with lead acetate @ 20mg/kg b.wt + Andrographis paniculata mediated selenium nanoparticles @ 5mg/kg b.wt. The treatment was given for 28 days. T2 group given lead acetate revealed a significant decrease in Hb, PCV, TEC, TLC, and lymphocyte count whereas neutrophil count was significantly increased. Serum total protein and albumin were significantly decreased while serum AST, ALT, creatinine, and BUN were significantly increased in group T2. However, the haematobiochemical values from T4 group showed non significant alteration when compared with control group except Hb. Thus A. paniculata mediated selenium nanoparticles supplementation along with lead acetate showed protective beneficial effect on hematobiochemical parameters during lead toxicity in mice.