HAEMATINIC ACTIVITY OF ECHURAMOOLI LEAF CHOORANAM IN PHENYLHYDRAZINE INDUCED ANAEMIC RATS

Abstract

Iron deficiency is the most common and widespread nutritional disorder in the world. India is among the countries with highest prevalence of anaemia in the world. It has serious consequences for the health and well - being as well as social and economic impacts of India . Untreated iron deficiency anaemia can become severe enough to interfere with daily life. Knowledge of iron deficiency and its treatment in Siddha Sys tem of medicine dates back from time immortal. Many plants in Siddha system of medicine are known to have remarkable effects in treating anaemia . One such medicine is “ Echuramooli Leaf Chooranam ” Aristolochia indica Linn. The haematinic activity of Echuram ooli Leaf Chooranam was studied in Phenylhydrazine induced anaemic r ats. Anaemia was induced by an oral administration of Phenylhydrazine for a period of 7 days. The Echuramooli Leaf Chooranam was administered at the various dose levels of 50 mg/kg, 100 mg /kg and 2 00 mg/kg oral ly to the animals for 14 days. Hb concentration, RBC count, PC V, MCH, MCHC were analysed as indices of anaemia. Phenylhydrazine significantly decrease the haematological parameters. After 14 days of treatment with trial drug Echuramoo li Leaf Chooranam at the dose level of 2 00 mg significantly reverse the above parameters and turn towards the normal va lue. This result supports the traditional use of Echuramooli Leaf Chooranam in the treatment of anaemia.