H3K27M-Positive Primary Spinal Glioblastoma Presenting with Hemorrhage—A Rare Clinical Entity

Abstract

Primary spinal glioblastoma multiforme is a rare and aggressive spinal tumor with dismal outcomes CASE DESCRIPTION: We have presented an unusual case-the first, to the best of our knowledge, to be reported-with intratumoral hemorrhage and sudden-onset quadriplegia in a patients with primary spinal glioblastoma multiforme. The patient underwent emergency surgical decompression. The patient died after a prolonged intensive care unit stay. The tumor was positive for histone molecular alteration, H3K27M.