H2O2 Screening from Saliva of Gum Diseased‐patient through CN‐dot Wrapped Cu2O Nano‐frogspawns Ionic Liquid Nanocomposite

Abstract

Listen

Translate article

AbstractHerein, we report the development of a robust, sensitive, and selective non‐enzymatic electrochemical sensor for the detection of hydrogen peroxide (H2O2). The novel BA modified CN‐dot wrapped Cu2O‐nano‐frogspawn (FS@CN‐dot) sensor probe demonstrated a catalytic property towards H2O2 that allowed the highly sensitive electrochemical detection at a low reduction potential. The as prepared CN‐dot wrapped Cu2O hetero‐structured nanocomposite was analyzed using surface analysis methods to confirm the morphology, crystallinity, and oxidation states of various constituents and dopant elements. Further, the morphological analysis of the Cu2O nanoparticles revealed that the Cu2O retains frogspawns‐liked structure. Under the optimized experimental conditions, the sensor showed a wide dynamic range of H2O2 from 0.5 μM to 9 mM with a detection limit (LD) of 1.2±0.1 nM. The designed sensing probe showed good stability, high sensitivity, and selectivity even in the presence of potential interfering molecules. To check the reliability of the fabricated sensor in biomedical applications, the proposed sensing probe was successfully applied to monitor H2O2 in saliva of a gum‐diseased patient. To the best of our knowledge, this report is the first of its kind not only because of its novel construction style in terms of CN source, but also in terms of real sample applicability as well.