Abstract
Purpose: Acid inhibition appears less effective in H. pylori negative individuals (Hp neg) than in H. pylori positive ones (Hp pos) with proton pump inhibitors but not with H2-antagonists and may result in insufficient control of heartburn (HB) in many subjects. We evaluated a bedtime provocative meal and response to treatment in healthy subjects (18–75 yrs) who tested Hp neg (429) or pos (61) with a history of nighttime HB (2 episodes/wk) rated as moderate to very severe.
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