H-InvDB: A Comprehensive Annotation Resource For Human Transcriptome

Abstract

H-Invitational Database (H-InvDB: "http://www.h-invitational.jp/":http://www.h-invitational.jp/) is a comprehensive annotation resource for human transcriptome. By extensive analyses of all human transcripts, we provide curated annotations of human genes, transcripts and proteins that include gene structures, alternative splicing isoforms, non-coding functional RNAs, protein functions, functional domains, sub-cellular localizations, metabolic pathways, protein 3D structure, genetic polymorphisms, relation with diseases, gene expression profiling, molecular evolutionary features, protein-protein interactions (PPIs) and gene families/groups. The latest release of H-InvDB (release 7.0) provides annotation for 296,912 human transcripts in 46,499 human gene clusters based on human full-length cDNAs, mRNAs and the reference human genome sequences (NCBI b37.1). H-InvDB consists of three main views, the Transcript view, the Locus view and the Protein view, and six sub-databases; G-integra, H-ANGEL, DiseaseInfo Viewer, Evola, PPI view and Gene Family/Group view. We also provide data mining tools such as “Navigation search”, an extended search system that enables complicated searches by combining 16 different search options ("http://www.h-invitational.jp/hinv/c-search/hinvNaviTop.jsp":http://www.h-invitational.jp/hinv/c-search/hinvNaviTop.jsp) and “H-InvDB Enrichment Analysis Tool (HEAT)”, a data mining tool for automatically identifying features specific to a given human gene set ("http://hinv.jp/HEAT/":http://hinv.jp/HEAT/).