Abstract

Objective: To compare the eyelid and orbital fat volume in different age groups. Material and Methods: Sixty seven orbits of 39 subjects with normal orbital computed tomography (CT) scans with an age range of 18-82 years were included in the study. Three dimentional (3D) connected threshold region growing algorithm as a plugin to Image J, an image analysis software package developed by National Institute of Health (NIH) (U.S. Department of Health and Human Services, USA) was used to measure the orbital and eyelid fat volume on axial computed tomography sections. Measurements were compared in three different age groups. Results: There were 16 orbits in the first group (18-34 years), 33 in the second (35-60 years) and 18 in the third group (61 and up). Total volume (Orbit + eyelid) and total fat volume (Orbital+ eyelid) was noted to increase with age (p= 0.0021). Eyelid fat volume also increased with age (p=0.0013). Total fat volume/Total volume (p= 0.0041) and Eyelid fat volume/Total volume (p= 0.0033) was noted to increase with age. Eyelid fat volume/Total fat volume also increased with age (p= 0.0042). Orbital fat volume showed a trend of increase with age but this was not found to be statistically significant. (p= 0.072) The proportion of mean orbital fat volume within mean total volume (p= 0.688) did not show any change with age. Conclusion: The total fat volume and eyelid fat volume as well as their percentage of the total volume increased with age. Percentage of eyelid fat volume of the total fat volume increased with age as well. These observations suggest that orbital fat expansion may occur with aging and fat excision may have a role in blepharoplasty for treatment of upper and lower eyelid prominence. This technique may be useful in further future studies regarding the anatomy and distribution of eyelid and orbital fat.

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