Abstract
Hydrogen sulfide (H2S) has been shown to enhance bone formation, but its osteogenic effect is unclarified during distraction osteogenesis (DO). This study tested the hypothesis that H2S could promote bone formation in a rabbit mandibular DO model. Unilateral mandibular lengthening was achieved in 26 rabbits. During the distraction and the first week of consolidation, saline 0.2mL or saline 0.2mL and GYY4137 (H2S donor, 50mg/kg) was injected intravenously twice a day. Distracted mandibles were examined by dual-energy x-ray absorptiometry, histology, computed tomography, and a 3-point bending test 8weeks after distraction. The GYY4137-treated animals presented a greater response as measured by bone mineral density and mechanical properties and a more mature microstructure of the lengthened mandibles compared with the saline-treated control animals. The results of this study suggest that H2S can accelerate osteogenesis during DO.
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