Gynäkologische Betreuung von Patientinnen mit HNPCC-Syndrom und deren Familien

Abstract

Female patients with diagnosis of endometrial or ovarian cancer before the age of 45 are suspicious of hereditary non-polyposis colorectal cancer (HNPCC). In the daily routine it is difficult to distinguish between HNPCC and sporadic cancer, however, the consequences are severe. A standardised interview was conducted to evaluate the management of HNPCC-patients in medical practice. COHORT AND METHODS: 36 gynecologists working in medical practice were interviewed, statistical analyses were performed with SPSS 12.0. Most of the gynecologists refer to a hereditary tumor syndrome in consideration of family history, diagnosis at early age and synchronous or metachronous cancer. Patients with endometrial or ovarian cancer before the age of 45 years were rated as high risk patients. 72 % of the gynecologists take care of female patients suspicious of HNPCC according to the Bethesda criteria, even though half of these do not consider that diagnosis. Gynecological surveillance examinations are not fully taken into account. The interdisciplinary surveillance concept is rarely initiated. The current surveillance recommendation for patients suspicious of HNPCC should be applied more often in the daily routine of gynecological outpatient management. Sponsored by Deutsche Krebshilfe.