Abstract
Endometriosis is a benign disease characterized by the presence of endometrial tissue outside the uterus. It is more associated to chronic pelvic pain, dysmenorrhea and dyspareunia. Adenomyosis is represented by the presence of endometrial tissue inside the uterine muscle. We studied, in 100 successive patients, immunohistochemical markers CD10, CD34 and KI67 in glandular and in stromal cells, in order to assess the correlation between symptoms and them. We did not find any data reporting these aspects. As CD34 is an angiogenesis marker and Ki67 is an aggressivity marker, pelvic pain could predict a more aggressive disease and with a higher spreading capacity in patients with endometriosis. In the same patients, and dysmenorrhea seems to be related with only with angiogenesis.
Highlights
Endometriosis is a benign disease characterized by the presence of endometrial tissue outside the uterus
Endometriosis is usually associated with infertility, chronic pelvic pain, dysmenorrhea and dyspareunia; while adenomyosis can be associated with chronic pelvic pain and - most of the time - with bleedings [3-8]
We studied all of the patients in terms of admission’s symptoms, dysmenorrhea, and dyspareunia and immunohistochemical markers: CD10, CD34, Ki67
Summary
Endometriosis is a benign disease characterized by the presence of endometrial tissue outside the uterus. There was a statistically significant difference according to the presence or the absence of chronic pelvic pain in group 1 in patients with CD34 positive or negative (p = 0.037 < 0.05). There was a statistically significant difference according to the presence or the absence of chronic pelvic pain in group 1 in patients with Ki67 for glandular cells positive or negative (p = 0.001 < 0.05).
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