Abstract
Phytochemicals prevent cancer either through blocking initiation by detoxification of carcinogens or through suppressing by apoptosis. In this study, we have identified a Gymnasterkoreayne B (GKB), a polyacetylene compound, isolated from Aster koraiensis as a major principle for a significant quinone reductase (QR) induction via Nrf2‐ Antioxidant response element (ARE) pathway. Furthermore, the induction of QR activity was increased by GKB in vivo. Interestingly, GKB induced apoptosis and p53 and p21 protein levels. In p53‐ or p21‐ knock out cells, Nrf2 activation and stabilization was decreased than wild type cells. However, apoptosis was induced by GKB in the knock out cells, and more induced in Nrf2 knock down cells. From the results, we can suggest that Nrf2 and p53 have a close relationship in cancer cell model induced by phytochemicals in terms of cancer chemoprevention. Taken together, we present here that GKB not only increases QR through Nrf2‐ARE pathway but also induces apoptosis through p53, and that it could be induced cancer chemoprevention effect by the cooperative regulation of both blocking and suppressing of cancer.Grant Funding Source: KIST‐Gangneung Institute intramural research grant (2Z03300)
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