Abstract
Aging is a root cause of many chronic diseases and associated morbidity and mortality. A number of interventions have been suggested to improve overall lifespan and health, with one of the most successful being dietary restriction. Despite the generally well-demonstrated health and longevity benefits of dietary restriction, cases remain in model organisms where some genotypes are not affected or are negatively impacted. With the use of the Drosophila Genetic Reference Panel, we have identified a new set of genes that regulate health or longevity either diet-dependently or diet-independently. Associated with longevity are the genes CG34351 and Fdxh. We have also revealed CG33690, a previously uncharacterized gene, as being a regulator of health in response to diet. Through alteration of the expression of these genes via RNAi and gene disruption, we have validated their roles in impacting on lifespan or climbing ability independently. In addition to ascribing novel functions to these genes, our results demonstrate that lifespan and healthspan depend on a complex set of inputs including genetic polymorphisms and diet.
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