Abstract
<p class="Abstract">Current research was conducted to find out the pharmacological basis of the methanolic extract of <em>Solanum surattense</em> for its traditional uses in constipation and diarrhea. In isolated rabbit jejunum preparations, <em>S. surattense</em> exhibited the spasmogenic effect at lower concentration (0.01-1.0 mg/mL) followed by the spasmolytic effect at next higher concentration (3-5 mg/mL) with EC<sub>50 </sub>value of3.17 mg/mL. <em>S. surattense</em> and verapamil (standard Ca<sup>2+</sup> channel blocker) caused an inhibition of K<sup>+ </sup>(80 mM)-induced contractions with EC<sub>50 </sub>value of0.85 and 0.15 mg/mL respectively, suggesting Ca<sup>2+ </sup>channels block-ade.Extract caused the rightward shift in Ca<sup>2+ </sup>concentration-response curve, similar to verapamil. Among the fractions, aqueous fraction showed the spasmogenic effect while dichloromethane fraction showed spasmolytic effect. It is concluded that methanolic extract of <em>S. surattense</em> contains spasmogenic and spasmolytic constituents, which explains its traditional uses in constipation and diarrhea.</p><p> </p>
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