Abstract
Investigators from the Department of Pediatric Neurology at the Children's Hospital of Fudan University assessed the gut microbiome in pediatric patients with intractable non-lesional epilepsy who were treated with the ketogenic diet (KD) comparing differences between responders and non-responders over a period of 6 months.
Highlights
Investigators from the Department of Pediatric Neurology at the Children’s Hospital of Fudan University assessed the gut microbiome in pediatric patients with intractable non-lesional epilepsy who were treated with the ketogenic diet (KD) comparing differences between responders and non-responders over a period of 6 months
Gut microbiome analysis was performed by 16s rDNA sequencing on fecal samples before and after initiation of KD and species diversity was compared between responders before and after treatment
The authors conclude the KD can reduce the diversity of intestinal bacteria and there are further differences in the composition between those that respond to the KD and those that do not
Summary
Investigators from the Department of Pediatric Neurology at the Children’s Hospital of Fudan University assessed the gut microbiome in pediatric patients with intractable non-lesional epilepsy who were treated with the ketogenic diet (KD) comparing differences between responders and non-responders over a period of 6 months. Twenty (14 males, 6 females) patients (median age at enrollment: 4.2 years, range 1.2-10.3 years) were treated with a classic 4:1 ratio ketogenic diet. After 6 months of KD treatment, 10 patients were considered responders (decreased in seizure frequency of ≥ 50%) with concomitant improvement in electroencephalography.
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