Abstract
Undernutrition is associated with gut microbiota unbalance, and probiotics are believed to restore it and improve gut integrity. A randomized double-blind controlled trial was conducted to evaluate the efficacy of gummy L. plantarum Dad-13 (108−9 CFU/3 g) to prevent the progression of severe undernutrition. Two groups of moderate undernutrition infants were involved in this study, namely the placebo (n = 15) and probiotics (n = 15) groups, and were required to consume the product for 50 days. 16S rRNA sequencing and qPCR were used for gut microbiota analysis, and gas chromatography was used to analyze Short-Chain Fatty Acid (SCFA). The daily food intake of both groups was recorded using food records. Our results revealed that the probiotic group had better improvements regarding the anthropometry and nutritional status. In addition, L. plantarum Dad-13 modulated the butyric acid-producing bacteria to increase and inhibit the growth of Enterobacteriaceae. This gut modulation was associated with the increment in SCFA, especially total SCFA, propionic, and butyric acid. The number of L. plantarum was increased after the probiotic intervention. However, L. plantarum Dad-13 was not able to change the alpha and beta diversity. Therefore, L. plantarum Dad-13 has been proven to promote the growth of beneficial bacteria.
Highlights
IntroductionAccording to the Indonesia Ministry of Health data, the number of infants with undernutrition exceeds that of infants with overnutrition [1]
As a developing country, Indonesia is facing a double burden of malnutrition
To emphasize that gut microbiota modulation is affected by the probiotic intervention, we evaluated the number of specific bacteria
Summary
According to the Indonesia Ministry of Health data, the number of infants with undernutrition exceeds that of infants with overnutrition [1]. The management of undernutrition is prioritized rather than overnutrition. Undernutrition is classified as stunting (low height-for-age), wasting (low weight-for-age), and underweight (low weight-for-height) [2]. According to the Z-score’s cut-off value, the severity of undernutrition is classified as moderate (between −2 and −3 SD) and severe (
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